HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Methylprednisolone Aceponate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Methylprednisolone 17-Propionate | HCID 10025718 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Methylprednisolone Aceponate | HCID 63019 | — |
Reaction Steps
Analogously to Example 1, 1.0 g of 11β,21-dihydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione is stirred in 10 ml of pyridine with 5 ml of acetic anhydride for one hour at room temperature and then worked up, thus isolating 790 mg of 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione, mp 138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587236 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-759df690686e4bae8fe7d3dd8ac9ca11 |
| Source note | uspto-grants-1986_05 |