Sodium Hydroxide → HCID 23322747, compound

HRID 279840Notes

Reaction equation

HRID 279840 reaction equation
[OH-].[Na+].C([O:5][C:6]([CH:8]([N:10]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH:12]([NH:19][CH:20]([C:29]([O:31]CC)=[O:30])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:11]1=[O:34])[CH3:9])=[O:7])C>C(O)C>[C:6]([CH:8]([N:10]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH:12]([NH:19][CH:20]([C:29]([OH:31])=[O:30])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:11]1=[O:34])[CH3:9])([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23322755HCID 23322755, compound

Product 1

HCID 23322747HCID 23322747, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The diastereomerically pure benzyl ester products of Example 3 are separately treated with excess lN NaOH in 50% ethanol at room temperature for 18 hours. Work-up according to Example 1 affords, after lyophilization, the title diastereomerically pure diacids. These same diacid products can also be prepared by saponification of the diethyl ester products of Example 4.

Workup

  1. customaffords

Sources & evidence

ORD record
ord-931b17c67cd740e1bf79d475d094953c
Source dataset
uspto-grants-1986_05
Patent number
US04587238

Reaction notes

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