Piperazin-1-ylpropanol → HCID 13505743, compound

HRID 279849Notes

Reaction equation

HRID 279849 reaction equation
CS[C:3]1[C:9]2=[CH:10][C:11]3[C:16]([N:8]2[CH2:7][C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[N:4]=1)=[CH:15][CH:14]=[CH:13][CH:12]=3.[N:21]1([CH2:27][CH2:28][CH2:29][OH:30])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(Cl)Cl>[CH:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[CH:10]=[C:9]1[N:8]2[CH2:7][C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[N:4]=[C:3]1[N:24]1[CH2:25][CH2:26][N:21]([CH2:27][CH2:28][CH2:29][OH:30])[CH2:22][CH2:23]1

Participants

4

Reactant 2

HCID 79207Piperazin-1-ylpropanolHCID 1350573612-methylthio-6H-indolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 13505743HCID 13505743, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5.39 g of 12-methylthio-6H-indolo[2,1-c][1,4]benzodiazepine, the product of Example 1c., and 17 g of 1-piperazinepropanol in a pressurized bottle was heated to 220° C. overnight. The reaction mixture was dissolved in CH2Cl2 and then was washed with water. Removal of solvent in vacuo followed by recrystallization from EtOH gave the title compound, a colorless solid, mp 174°-175° C.

Workup

  1. washwas washed with water
  2. customRemoval of solvent in vacuo
  3. customfollowed by recrystallization from EtOH

Sources & evidence

ORD record
ord-0035b7d888814c84a5c7bbe4acab9b34
Source dataset
uspto-grants-1986_05
Patent number
US04587244

Reaction notes

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