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4-Methylcyclohexanone → Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylcyclohexanone | HCID 11525 | — |
| 反応物 | L-Cysteine, methyl ester, hydrochloride | HCID 2733208 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl (3R)-8-methyl-1-thia-4-azaspiro[4.5]decane-3-carboxylate hydrochloride | HCID 86740772 | — |
反応手順
34.3 g of L-cysteine methyl ester hydrochloride and 15.4 ml of 4-methylcyclohexanone are suspended in 70 ml of methanol and the suspension is refluxed for 3 hours. The suspension is concentrated to dryness under reduced pressure and the residue is recrystallized from isopropanol/methanol to give 25 g of colorless crystals of melting point 180° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04587250 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-8dfe6a8dff9f400ebc720d0b424d8c3a |
| 出典メモ | uspto-grants-1986_05 |