HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 6'-Fluoro-2-iminospiro[1,3-thiazolidine-5,4'-2,3-dihydrochromene]-4-one | HCID 140342188 | — |
| Product | (+/-)-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione | HCID 13998516 | — |
Reaction Steps
2.195 g of (±)-6-fluoro-2,3-dihydro-2'-iminospiro-[4H-1-benzopyran-4,5'-thiazolidin]-4'-one were dissolved in 12 ml of methanol and 12 ml of 37% aqueous hydrochloric acid and the solution was boiled overnight. The colorless crystals which separated were removed and washed with water. After drying in vacuo, there was obtained (±)-6-fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione of melting point 147°-149° C. (95% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587256 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-ce5fab026765488aa7536d02032f0644 |
| Source note | uspto-grants-1986_05 |