反应详情

5.4 g of sodium methylate were added portionwise at 60° C. to 112.1 g of 4-fluoro-phenol. After 10 minutes, the mixture was treated with 500 ml of acrylonitrile, boiled in an oil-bath for 48 hours, thereafter poured into 3 l of water and extracted with chloroform. After drying the organic phase with sodium sulfate, it was concentrated completely in vacuo. There was obtained 3-(4-fluoro-phenoxy)propionitrile as a viscous oil.

1. waitboiled in an oil-bath for 48 hours
2. extractionextracted with chloroform
3. dry with materialAfter drying the organic phase with sodium sulfate, it
4. concentrationwas concentrated completely in vacuo