Acetic Acid → (+/-)-6-fluoro-8-acetamido-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione

関与物質

反応手順

61 mg of (±)-6-fluoro-8-amino-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione were heated to 50° C. for 90 minutes in a mixture of 1.2 ml of glacial acetic acid and 1.2 ml of acetic acid anhydride and the resulting mixture was subsequently concentrated to dryness in vacuo. After boiling up briefly with active carbon in methanolic solution, the residue was crystallized from methanol and yielded (±)-6-fluoro-8-acetamido-2,3-dihydrospiro[4H-1-benzopyran-4,5'-thiazolidine]-2',4'-dione in the form of a light brownish material of melting point 278°-280° C.

情報源と証拠