HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dihydro-2,5-dimethyl-4-chloro-7-nitrobenzofuran → 7-Amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dihydro-2,5-dimethyl-4-chloro-7-nitrobenzofuran | HCID 13575677 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran | HCID 13630884 | — |
Reaction Steps
51.0 g of 3C was dissolved in 600 ml of THF. The solution was divided in half, and each half was hydrogenated (40-50 psig hydrogen pressure) in the presence of 1 g of palladium-on-charcoal catalyst. The final combined reaction mixtures were filtered, the filtrates were combined, dried (MgSO4) and evaporated to dryness, to give 7-amino-2,3-dihydro-2,5-dimethyl-4-chlorobenzofuran (3D).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587259 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-0304a65309b845ad8c043a8dab4a862a |
| Source note | uspto-grants-1986_05 |