Guanidine → 5-[(Quinolin-3-yl)methyl]pyrimidine-2,4-diamine

Participants

Reaction Steps

2-(3-Quinolylmethyl)-3-anilinoacrylonitrile (6.38 g) was treated with guanidine in the manner of Example 5B. There was isolated 4.90 g (87%) of 2,4-diamino-5-(3-quinolylmethyl)pyrimidine which was recrystallized from methyl cellosolve with the aid of decolorizing charcoal; m.p. 279°-282° C. (dec). Anal. Calcd. for C14H13N5 : C, 66.92; H, 5.21; N, 27.87. Found: C, 66.57; H, 5.36; N, 27.54.

Provenance & Evidence