2,4-Diamino-5-(1,2,3,4-tetrahydro-8-methoxy-6-quinolylmethyl)pyrimidine → 5-[(8-Methoxyquinolin-6-yl)methyl]pyrimidine-2,4-diamine

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Reaction Conditions

Reaction Steps

The product of Example 2 was oxidised using 20% palladium on charcoal in 50 ml of cumene, by heating at 150° C. for 21 hours. After the catalyst was removed and the solvent evaporated, the residue was purified on a silica gel column which was eluted with methylene chloride:methanol/19:1. This produced 0.51 g (35%) of the title compound, which melted at 285°-287° after recrystallisation from betamethoxyethanol. Anal. Calcd. for C15H15N5O: C, 64.04; H, 5.37; N, 24.89. Found: C, 63.88; H, 5.37; N, 24.84.

Provenance & Evidence