Ethanol → HCID 23323065, compound

Participants

Reaction Steps

The product of Example 12 (0.78 g, 2.5 mmol) was dissolved in 35 ml of β-methoxyethanol, and then 0.06 g of 5% Pd/C and 0.3 ml of 95% hydrazine were added, and the reation was refluxed for 1 hour. The Pd/C was filtered off, the solvent removed, and the product was purified on a silica gel column which was eluted with 7% methanol in methylene chloride. This gave 0.48 g (69% yield) of the free base which was recrystallised as the dihydrochloride salt from ethanol, mp 303°-305° dec. Anal. Calcd. for C15H16N6.2HCl.0.5H2O: C, 49.73; H, 5.29; N, 23.20; Cl, 19.57. Found: C, 49.71; H, 5.30; N, 23.18; Cl, 19.51.

Provenance & Evidence