HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → 5-[(4,8-Dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-(Phenylamino)propanenitrile | HCID 15576825 | — |
| Reactant | HCID 67937090 | HCID 67937090 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-[(4,8-Dimethoxy-2-methylquinolin-6-yl)methyl]pyrimidine-2,4-diamine | HCID 14570338 | — |
Reaction Steps
The aldehyde from above was converted to 2-(4,8dimethoxy-2-methyl-6-quinolylmethyl)-3-anilinoacrylonitrile with anilinopropionitrile and sodium methylate in dimethyl sulfoxide on a 1.4 mmol scale in the same manner as in Example 5-A. The crude product from this reaction was condensed with guanidine hydrochloride and sodium methylate in ethanol as in Example 5-B to give the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587341 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-151bb5f14ab9486c814ab0388aad64d4 |
| Source note | uspto-grants-1986_05 |