HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate → Methyl 7,8-dimethoxy-2H-1-benzopyran-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate | HCID 12849835 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | N,N-Diethylaniline | HCID 7061 | — |
| Product | Methyl 7,8-dimethoxy-2H-1-benzopyran-5-carboxylate | HCID 12849831 | 100% |
Reaction Steps
Methyl 3,4-dimethoxy-5-(2-propynyloxy)benzoate (390 g, 1.56 mol) in N,N-diethylaniline (0.4 L) was refluxed for 40 min. The solution was cooled and diluted with methylene chloride (2 L). The organic solution was extracted with 1N hydrochloric acid (5×1 L), dried (MgSO4) and concentrated to give title compound (390 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587342 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-a6af8e623b8d4dbfab279786ada31671 |
| Source note | uspto-grants-1986_05 |