反应详情

A mixture of sodium methoxide (7.02 g, 0.13 mole), 7,8-dimethoxy-5-formyl-2H-1-benzopyran (57 g, 0.26 mole) and 3-ethoxypropanenitrile (28.35 g, 0.286 mole) in methanol (150 mL) was heated at reflux for 4 hr, allowed to cool and diluted with water (150 mL) and ethylether (500 mL). The layers were separated and the ether portion was washed with water (3×250 mL and 1×100 mL) and dried over magnesium sulfate. The ether solution was concentrated to give 55 g (73%) of an amber oil which was used without further purification.

1. temperaturewas heated
2. temperatureat reflux for 4 hr
3. temperatureto cool
4. customThe layers were separated
5. washthe ether portion was washed with water (3×250 mL and 1×100 mL)
6. dry with materialdried over magnesium sulfate
7. concentrationThe ether solution was concentrated