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HRID280045

反应详情

EQUATION

反应方程式

HRID 280045 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)CCCCC(=O)O
HCID98810

6-Oxoheptanoic acid

C7H12O3

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCC(=O)OCc1ccccc1
HCID13934182

未命名化合物

结构：CC(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)NCC(=O)OCc1ccccc1
HCID54160731

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)CCCCC(=O)Nc1ccc(C[C@H](NC(C)=O)C(=O)NCC(=O)OCc2ccccc2)cc1
HCID53767188

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The mixed anhydride coupling was performed as described for the synthesis of compound 13 with 6-oxo-n-heptanoic acid (97 mg, 0.67 mmol) and the product from above, compound 15 (238 mg, 0.67 mmol). Each component was dissolved in 10 ml of dry tetrahydrofaran. Yield 111 mg (34%), mp 177.5°-180.5° C., [α]D25 =+19.5 (c.=1.4, methanol). Anal. calc. for C27H33N3O6 (493.58): C, 65.44; H, 6.71; N, 8.48. Found: C, 65.46; H, 6.74; N, 8.61.

WORKUP

后处理

  1. dissolutionEach component was dissolved in 10 ml of dry tetrahydrofaran