HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 2,3,4-trimethoxybenzenesulfonyl Chloride | HCID 4712742 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide | HCID 13645632 | — |
Reaction Steps
2,3,4-Trimethoxybenzene sulfonyl chloride (20.4 g, 0.765 m) in methylene chloride (100 ml) was added dropwise to 3-aminopropanol (17.2 g) in methylene chloride (300 ml). After stirring overnight the reaction was washed with dilute aqueous HCl, dried and stripped to provide a solid. Trituration with diethyl ether provided the product N-(3-hydroxypropyl)-2,3,4-trimethoxy-benzenesulfonamide, m.p. 95°-97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04587360 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-2a8de3b233524fb4987aa632861c0049 |
| Source note | uspto-grants-1986_05 |