HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 280060Generated: October 26, 2026
Acetic Anhydride → furo(3,4-b)pyridin-5(7H)-one
https://huagongshe.com/reaction/280060
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Furo[3,4-b]pyridine-5,7-dione | HCID 69688 | — |
| Reactant | N,N-Diethyl-m-phenetidine | HCID 74625 | — |
| Reactant | 1H-Indole, 2-methyl-1-octyl- | HCID 170708 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | furo(3,4-b)pyridin-5(7H)-one | HCID 819439 | 303.5% |
Reaction Steps
6.0 g of quinolinic anhydride, 9.5 g of N-octyl-2-methylindole and 0.56 g of zinc chloride are stirred in 30 ml of glacial acetic acid at 20° C. for 5 hours. 6.6 g of 3-diethylaminophenetole and 8 ml of acetic anhydride are then added, after which the mixture is stirred at 50° C. for 21/2 hours. The product is precipitated with 30% aqueous ammonia, separated from the aqueous phase and recrystallised from isopropanol, affording 16.5 g of the isomer-free 4-azaphthalide compound of the formula ##STR16## of melting point 113°-118° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04587539 |
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| Source dataset | uspto-grants-1986_05 |
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| ORD ID | ord-3aea14e105664764a1ddfa9feaffda81 |
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| Source note | uspto-grants-1986_05 |
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