反应详情

Hydroxy(tosyloxy)iodobenzene (78.5 g) was added to a solution of 1,1,1-trifluoropentane-2,4-dione in acetonitrile (500 ml). The mixture was heated under reflux for 45 minutes, then cooled, and thiourea (15.2 g) was added. The mixture was heated under reflux for 4 hours and then left to stand overnight. Evaporation and crystallisation of the residue from dichloromethane gave the title compound.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 45 minutes
3. temperaturecooled
4. temperatureThe mixture was heated
5. temperatureunder reflux for 4 hours
6. waitleft
7. customEvaporation and crystallisation of the residue from dichloromethane