反应详情

23.2 g of cyclopropylamine are added dropwise to a solution of 123.9 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate in 250 ml of ethanol, cooling in ice and stirring. When the exothermic reaction has subsided, the mixture is stirred at room temperature for 1 hour, the solvent is removed in vacuo, and the residue is recrystallized from cyclohexane/petroleum ether. 115 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate of melting point 63°-65° C. are obtained.

1. temperaturecooling in ice
2. customWhen the exothermic reaction
3. stirringthe mixture is stirred at room temperature for 1 hour
4. customthe solvent is removed in vacuo
5. customthe residue is recrystallized from cyclohexane/petroleum ether