Methanol → HCID 13649429, compound

Participants

Reaction Steps

A solution of 20 mg of 5-[p-(2-carbomethoxyprop-2-enyl)phenyl]imidazo[1,5-a]pyridine and 20 mg of sodium methoxide in 2 ml. of methanol is stirred under nitrogen for 1 hour at 25°. To the reaction mixture 2 ml. of water is added, and the homogenous solution is stirred at room temperature for 18 hours. The solvent is evaporated and the residue is redissolved in 5 ml of water and washed with 3 ml of ether. Acidification to pH=5, extraction with 10 ml of methylene chloride, drying over magnesium sulfate and evaporation yields 5-[p-(2-carboxyprop-2-enyl)phenyl]imidazo[1,5-a]pyridine, m.p. 171°-172°.

Provenance & Evidence