Formic Acid → HCID 13649442, compound

Participants

Reaction Steps

A solution of 6-aminomethyl-2-(p-ethoxycarbonylphenyl)pyridine (10.76 g) in 10 ml of formic acid is heated at 90° for 15 hours. The reaction is cooled to 0°, basified with excess saturated ammonium hydroxide solution and extracted with chloroform (4×30 ml). The organic extracts are dried and evaporated to yield 2-(p-ethoxycarbonylphenyl)-6-formylaminomethylpyridine which is recrystallized from toluene, m.p. 119.5°-120.5°.

Provenance & Evidence