反应详情

5-[p-(hydroxymethyl)phenethyl]imidazo[1,5-a]pyridine (2.52 g) is refluxed in 20 ml of thionyl chloride for 2 hours. Excess thionyl chloride is evaporated and the residue is partitioned between ethyl acetate and dilute sodium bicarbonate solution. The organic phase is dried over sodium sulfate and evaporated to yield 5-[p-(chloromethyl)-phenethyl]imidazo[1,5-a]pyridine.

1. customExcess thionyl chloride is evaporated
2. customthe residue is partitioned between ethyl acetate and dilute sodium bicarbonate solution
3. dry with materialThe organic phase is dried over sodium sulfate
4. customevaporated