HCID 54552716, compound → HCID 53977277, compound

HRID 280225Notes

Reaction equation

HRID 280225 reaction equation
C([O:3][C:4]([C:6]([CH3:25])=[CH:7][C:8]1[CH:24]=[CH:23][C:11]([CH2:12][CH2:13][C:14]2[N:19]3[CH:20]=[N:21][CH:22]=[C:18]3[CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[O:5])C>[OH-].[Na+]>[C:4]([C:6]([CH3:25])=[CH:7][C:8]1[CH:24]=[CH:23][C:11]([CH2:12][CH2:13][C:14]2[N:19]3[CH:20]=[N:21][CH:22]=[C:18]3[CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 54552716HCID 54552716, compound

Product 1

HCID 53977277HCID 53977277, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

5-[p-(2-Ethoxycarbonylprop-1-enyl)phenethyl]imidazo[1,5-a]pyridine (0.33 g) in 10 ml of 0.5N sodium hydroxide is refluxed for 3 hours, cooled and extracted with ether. The aqueous phase is adjusted to pH=6 and the resulting solid is filtered off to yield 5-[p-(2-carboxyprop-1-enyl)phenethyl]imidazo[1,5-a]pyridine.

Workup

  1. temperaturecooled
  2. extractionextracted with ether
  3. filtrationthe resulting solid is filtered off

Sources & evidence

ORD record
ord-d7aad3f0b1514a8e8dd977eeb180f61c
Source dataset
uspto-grants-1986_05
Patent number
US04588732

Reaction notes

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