反应详情

A solution of 3-benzyloxy-6-chloromethyl-2-methylpyridine (8.02 g) and sodium azide (5.98 g) in 400 ml of ethanol is heated at 80° for 4 hours. The reaction mixture is cooled, filtered and evaporated to yield a residue which is partitioned between ice-cold 0.5N NaOH (150 ml) and ether (150 ml). The organic phase is dried over sodium sulfate and evaporated to yield 6-azidomethyl-3-benzyloxy-2-methylpyridine, NMR: δ(CDCl3) 2.47 (3H), 4.27 (2H), 4.95 (2H).

1. temperatureThe reaction mixture is cooled
2. filtrationfiltered
3. customevaporated
4. customto yield a residue which
5. customis partitioned between ice-cold 0.5N NaOH (150 ml) and ether (150 ml)
6. dry with materialThe organic phase is dried over sodium sulfate
7. customevaporated