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Water → 6-Aminomethyl-3-benzyloxy-2-methylpyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Aluminum;lithium | HCID 16211445 | — |
| 反応物 | 6-Azidomethyl-3-benzyloxy-2-methylpyridine | HCID 23321862 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6-Aminomethyl-3-benzyloxy-2-methylpyridine | HCID 23321889 | — |
反応手順
Lithium aluminum hyride (1.27 g) is added to a solution of 6-azidomethyl-3-benzyloxy-2-methylpyridine (7.18 g) in 120 ml of dry ether at room temperature. After stirring for 45 minutes, 1.3 ml of water, 1.3 ml of 15% sodium hydroxide and 3.8 ml of water are added sequentially. The salts are filtered off and the filtrate is evaporated to yield 6-aminomethyl-3-benzyloxy-2-methylpyridine; NMR: (CDCl3) 1.67 (2H), 2.47 (3H), 3.8 (2H), 4.95 (2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04588732 |
| 出典データセット | uspto-grants-1986_05 |
| ORD ID | ord-4b51ad092c3a4cdd9124407c6634aca4 |
| 出典メモ | uspto-grants-1986_05 |