反应详情

A mixture of 24.5 g of 4-propoxyaniline, 19.8 g of 2,6-dichloro-3-nitrobenzoic acid, and 150 ml N,N-dimethylaniline was heated under nitrogen at 100° overnight. The cooled reaction mixture was treated with dilute base and chloroform. After the aqueous layer was washed several times with chloroform, it was treated with hydrochloric acid and the resulting orange needles were collected by filtration and washed with water to give 6-chloro-3-nitro-2-[(4-propoxyphenyl)amino]benzoic acid, mp 194°-196° C.

1. temperaturewas heated under nitrogen at 100° overnight
2. customThe cooled reaction mixture
3. additionwas treated
4. washAfter the aqueous layer was washed several times with chloroform, it
5. additionwas treated with hydrochloric acid
6. filtrationthe resulting orange needles were collected by filtration
7. washwashed with water