Formic Acid → HCID 23322137, compound

HRID 280275Notes

Reaction equation

C(OC(=O)C)(=O)C.[CH:8]([OH:10])=O.[BrH:11].[CH2:12]([N:15]([CH2:28][CH2:29][CH3:30])[CH:16]1[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][C:20]([NH2:27])=[C:21]([OH:26])[CH:22]=2)[CH2:17]1)[CH2:13][CH3:14]>C(OCC)C>[BrH:11].[CH2:28]([N:15]([CH2:12][CH2:13][CH3:14])[CH:16]1[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][C:20]([NH:27][CH:8]=[O:10])=[C:21]([OH:26])[CH:22]=2)[CH2:17]1)[CH2:29][CH3:30]

Participants

Conditions

Temperature: 0 °C

Procedure

0.7 ml of acetic anhydride is added to 3 ml of 98% formic acid, kept at 0° C., and the whole is left for 15 minutes at 0° C. 2.2 g of 2-dipropylamino-7-amino-6-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide are then added thereto and the mixture is then stirred for one hour at 0° C. After 50 ml of diethyl ether have been added and the solid has been filtered off, the latter is recrystallised from a 50/50 methanol/ethyl acetate mixture. This gives 1 g of the final product melting at 213° C. (with decomposition).

Workup

customkept at 0° C.
filtrationthe solid has been filtered off
customthe latter is recrystallised from a 50/50 methanol/ethyl acetate mixture

Sources & evidence

ORD record: ord-b5df7130bae74c00ae429f5bee953272
Source dataset: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04588747

Reaction notes

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