Sodium Methoxide → HCID 135674610, compound

HRID 280279Notes

Reaction equation

HRID 280279 reaction equation
C[O-].[Na+:3].[Cl:4][C:5]1[CH:6]=[C:7]([CH3:27])[C:8]([OH:26])=[C:9]([C:11](=[N:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:10]=1>CO>[Cl:4][C:5]1[CH:6]=[C:7]([CH3:27])[C:8]([OH:26])=[C:9]([C:11](=[N:19][CH2:20][CH2:21][CH2:22][C:23]([O-:25])=[O:24])[C:12]2[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=2)[CH:10]=1.[Na+:3]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 135674608HCID 135674608, compound

Product 1

HCID 135674610HCID 135674610, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of sodium methoxide (11.68 ml; 0.748 N, 0.0087 mol) is added to a solution of the acid product of Example 4 (3.2 g; 0.0087 mol) in methanol (200 ml). The mixture is evaporated to dryness in vacuo at 30° C., 150 ml of diethyl ether are added and the mixture is evaporated to dryness again. The residue is taken up in diethyl ether and filtered off. The yellow solid is dried in a vacuum desiccator in the presence of P2O5.

Workup

  1. customThe mixture is evaporated to dryness in vacuo at 30° C.
  2. addition150 ml of diethyl ether are added
  3. customthe mixture is evaporated to dryness again
  4. filtrationfiltered off
  5. dry with materialThe yellow solid is dried in a vacuum desiccator in the presence of P2O5

Sources & evidence

ORD record
ord-0772b866a0bf433ca33d818513f3c37c
Source dataset
uspto-grants-1986_05
Patent number
US04588748

Reaction notes

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