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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 28028Generated: October 28, 2026

7-Phenylacetamido-8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo[4.2.0]octane → 1-(2-Tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone

https://huagongshe.com/reaction/28028

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-Phenylacetamido-8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo[4.2.0]octaneHCID 12804735—
Reactant1-(2-Tetrahydropyranyl)-3-amino-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinoneHCID 21163112—
Product1-(2-Tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinoneHCID 54145837—

Reaction Steps

Following the procedure described for the preparation of 7-phenylacetamido-8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo-[4.2.0]octane from 7-amino-8-oxo-2,2-dimethyl-3-oxa-1-azabicyclo[4.2.0]octane (Example 6) and using 1-(2-tetrahydropyranyl)-3-amino-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone there is obtained 1-(2-tetrahydropyranyl)-3-phenylacetamido-4-[2-(2-tetrahydropyranyl)oxyethyl]-2-azetidinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04224336
Source datasetuspto-grants-1980_09
ORD IDord-b922538a62834907a1641f96b953c8c3
Source noteuspto-grants-1980_09