HCID 329651, compound → HCID 25242722, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-hydroxy-α-(1-imidazolyl)-acetophenone (3.5 g), and benzaldehyde (200 ml) was heated at 110° C. for 8 hours. The benzaldehyde was evaporated under reduced pressure and the residue, taken up with CH2Cl2 (100 ml), washed with H2O, was extracted with a solution of 8% HCl. The acid solution, neutralized with NaHCO3, extracted with CH2Cl2, dried and evaporated, gave 2 g of trans 2-phenyl-3-(1-imidazolyl)-2,3-dihydro-4H-1-benzopyran-4-one m.p. 199°-203° C.

Provenance & Evidence