N,N-dimethyl-2-benzyl-3-(4-trifluoromethylphenoxy)-propylamine oxalate → N-Methyl-2-benzyl-3-(4-trifluoromethylphenoxy)-propylamine oxalate

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Reaction Steps

Illustrative of the invention, N,N-dimethyl-2-benzyl-3-(4-methylmercaptophenoxy)-propylamine oxalate and N,N-dimethyl-2-benzyl-3-(4-trifluoromethylphenoxy)-propylamine oxalate at an oral dose of 30 mg/kg p.o show about 80% and 60% inhibition respectively of 3H-5HT uptake. N-Methyl-2-benzyl-3-(4-trifluoromethylphenoxy)-propylamine oxalate gives about a 50% inhibition of 3H-5HT uptake at a dose of 10 mg/kg p.o.

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