HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Methylphenethylamine → N-(2-(4-Methylphenyl)ethyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Methylphenethylamine | HCID 76751 | — |
| Reactant | 2-(3-Chlorophenyl)-2-oxoacetaldehyde | HCID 12463893 | — |
| Product | N-(2-(4-Methylphenyl)ethyl)-2-hydroxy-2-(3-chlorophenyl)ethanamine | HCID 23322163 | — |
Reaction Steps
The title compound was prepared in the manner described in Example 9 using 3-chlorophenylglyoxal and 2-(4-methylphenyl)ethanamine. Recrystallization of the chromatographed material from cyclohexane gave the title compound m.p. 85-88 (analysed as the hemi-hydrate). τ(CDCl3) 7.7 (3H, s), 7.0-7.5 (6H, m, +2H disappears with D2O), 5.4 (1H, dd), 2.9 (4H, s), 2.6-2.8 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04588749 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-43a6858edb474264a9a6913d44a86668 |
| Source note | uspto-grants-1986_05 |