反应详情

4-Methylbenzyl cyanide (10 g) in ether was added dropwise under nitrogen to lithium aluminium hydride (2.9 g) in ether. The solution was refluxed for 1 h at the end of addition. The reaction mixture was cooled, water (3 ml), 2N.NaOH (3 ml), and further water (9 ml) were added, the reaction mixture filtered, the residue washed with chloroform and the combined solvents dried (MgSO4). Evaporation gave 2-(4-methylphenyl)ethanamine (11.59 g).

1. temperatureThe solution was refluxed for 1 h at the end of addition
2. temperatureThe reaction mixture was cooled
3. filtrationthe reaction mixture filtered
4. washthe residue washed with chloroform
5. dry with materialthe combined solvents dried (MgSO4)
6. customEvaporation