Ammonia → HCID 13588034, compound

Participants

Reaction Steps

A mixture of 15 parts of 4-[[3-[(4-fluorophenyl)methyl]-3H-imidazo [4,5-b]pyridin-2-yl]amino]-1-piperidineacetonitrile and 400 15 parts of methanol saturated with ammonia was hydrogenated at normal pressure and at room temperature with 3 parts of Raney-nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was crystallized from a mixture of acetonitrile and 2,2'-oxybis-propane, yielding 10 parts (68%) of N-[1-(2-aminoethyl)-4-piperidinyl]-3-[(4-fluorophenyl)methyl]-3H-imidazo[4,5-b]pyridin-2-amine; mp. 174.5° C. (50). In a similar manner there were also prepared:

Provenance & Evidence