Methyl Isocyanate → HCID 13653890, compound

Participants

Reaction Steps

A mixture of 0.6 parts of isocyanatomethane, 4.43 parts of N-[1-[2-(4-aminophenyl)ethyl]-4-piperidinyl]-1-(4-fluorophenylmethyl)-1H-benzimidazol-2-amine and 135 parts of tetrahydrofuran was stirred for 3 hours at room temperature. The precipitated product was filtered off and crystallized from acetonitrile, yielding 2 parts (39.9%) of N-[4-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]phenyl]-N'methylurea; mp. +300° C. (compound 57).

Provenance & Evidence