HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Hydroxymethyl)pyrrolidin-2-one → (4S)-4-cyclohexyl-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Hydroxymethyl)pyrrolidin-2-one | HCID 558359 | — |
| Reactant | (R)-Tetrahydro-3-phenyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one | HCID 13573803 | — |
| Reactant | (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol | HCID 13648259 | — |
| Product | (4S)-4-cyclohexyl-L-proline | HCID 9815559 | — |
Reaction Steps
(trans)-4-Cyclohexyl-L-proline was prepared from 5-hydroxymethyl-2-pyrrolidone using the procedure described in Example 1, but substituting the following methodology for preparing (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol from (R)-tetrahydro-3-phenyl-3H,5H-pyrrolo[1,2-c]oxazol-5-one:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04588819 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-8973e0a2498e4129a041fd5f98359b23 |
| Source note | uspto-grants-1986_05 |