1-Chloro-4-(chloromethyl)benzene → 2-[2'-(4"-Chlorobenzylthio)-5'-chlorophenyl]-imidazoline hydrochloride

HRID 280426Notes

Reaction equation

HRID 280426 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:13][C:8]3([NH:12][CH2:11][CH2:10][NH:9]3)[C:6]=2[CH:7]=1.[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19]Cl)=[CH:17][CH:16]=1>CO>[ClH:1].[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19][S:13][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=2[C:8]2[NH:12][CH2:11][CH2:10][N:9]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 704691194-Chlorobenzothietane-2-spiro-2'-imidazoline

Product 1

HCID 704698232-[2'-(4"-Chlorobenzylthio)-5'-chlorophenyl]-imidazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

53 Parts of 4-chlorobenzothietane-2-spiro-2'-imidazolidine is reacted with 40 parts of p-chlorobenzyl chloride in 500 parts of methanol as described in Example 11. The yield is 84 parts (91% of theory) and the melting point is 248° to 250° C.).

Sources & evidence

ORD record
ord-429e62cdfaac4cacb3b0ac5b294adba4
Source dataset
uspto-grants-1986_05
Patent number
USRE032154

Reaction notes

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