反应详情

5-Methyl-1-tert-butyl-1H-pyrazole-4-carboxylic acid, ethyl ester (30 grams, 0.14 mole) and N-bromosuccinimide (25.4 grams, 0.14 mole) were combined in 100 ml of carbon tetrachloride. A heating lamp was turned onto the reaction mixture, and the reaction mixture was refluxed for three hours. The reaction mixture was then cooled and filtered to remove the succinimide. The filtrate was washed with water, washed with saturated brine, and dried over sodium sulfate and filter paper. The solvent was then removed in vacuo, providing 34.5 grams of the 5-(bromomethyl)-1-tert-butyl-1H-pyrazole-4-carboxylic acid, ethyl ester.

1. customA heating lamp was turned onto the reaction mixture
2. temperaturethe reaction mixture was refluxed for three hours
3. temperatureThe reaction mixture was then cooled
4. filtrationfiltered
5. customto remove the succinimide
6. washThe filtrate was washed with water
7. washwashed with saturated brine
8. dry with materialdried over sodium sulfate
9. filtrationfilter paper
10. customThe solvent was then removed in vacuo