Chloroform → HCID 13138216, compound

HRID 28050Notes

Reaction equation

HRID 28050 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:24])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:19]([O:21][CH3:22])[N:18]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:10])=[O:9])[CH:7]=1.[C:25]([O:28][C:29](=O)[CH3:30])(=[O:27])[CH3:26].[CH:32](Cl)(Cl)Cl>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:32])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:29]([O:28][CH3:25])[CH:30]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:9])=[O:10])[CH:7]=1.[C:25]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:24])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:19]([O:21][CH3:22])[N:18]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:10])=[O:9])[CH:7]=1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 7918Acetic AnhydrideHCID 20455856HCID 20455856, compound

Product 2

HCID 13138216HCID 13138216, compoundHCID 204558585-acetamido-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide

Procedure

To a solution of 37.3 g of 5-amino-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide prepared in a minimum amount of boiling chloroform, is added with vigorous stirring 20.4 g of acetic anhydride. The resulting mixture is then refluxed for 2 hours, the chloroform, excess acetic anhydride and acetic acid are removed in vacuo to yield as residue the desired product, 5-acetamido-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide.

Workup

  1. additionis added
  2. temperatureThe resulting mixture is then refluxed for 2 hours
  3. customthe chloroform, excess acetic anhydride and acetic acid are removed in vacuo

Sources & evidence

ORD record
ord-536633c1244a4c5e848efc64e2884d0c
Source dataset
uspto-grants-1980_09
Patent number
US04225337

Reaction notes

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