HRID28050

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6212

Chloroform

CHCl3

HCID7918

Acetic anhydride

C4H6O3

结构：COc1nc(C)nc(NC(=O)NS(=O)(=O)c2cc(N)ccc2Cl)n1

HCID20455856

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C)nc(NC(=O)NS(=O)(=O)c2cc(N)ccc2C)n1

HCID13138216

未命名化合物

结构：COc1nc(C)nc(NC(=O)NS(=O)(=O)c2cc(NC(C)=O)ccc2Cl)n1

HCID20455858

未命名化合物

PROCEDURE

实验过程

To a solution of 37.3 g of 5-amino-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide prepared in a minimum amount of boiling chloroform, is added with vigorous stirring 20.4 g of acetic anhydride. The resulting mixture is then refluxed for 2 hours, the chloroform, excess acetic anhydride and acetic acid are removed in vacuo to yield as residue the desired product, 5-acetamido-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide.

WORKUP

后处理

additionis added
temperatureThe resulting mixture is then refluxed for 2 hours
customthe chloroform, excess acetic anhydride and acetic acid are removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-536633c1244a4c5e848efc64e2884d0c
来源数据集: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04225337
来源说明: uspto-grants-1980_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:24])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:19]([O:21][CH3:22])[N:18]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:10])=[O:9])[CH:7]=1.[C:25]([O:28][C:29](=O)[CH3:30])(=[O:27])[CH3:26].[CH:32](Cl)(Cl)Cl>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:32])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:29]([O:28][CH3:25])[CH:30]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:9])=[O:10])[CH:7]=1.[C:25]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:24])=[C:6]([S:8]([NH:11][C:12]([NH:14][C:15]2[N:20]=[C:19]([O:21][CH3:22])[N:18]=[C:17]([CH3:23])[N:16]=2)=[O:13])(=[O:10])=[O:9])[CH:7]=1)(=[O:27])[CH3:26]