Acetic Anhydride → HCID 86740803, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-7-methoxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride, 1.5 ml of acetic anhydride and 1.5 ml of acetic acid is stirred at 110° C. for 4 hours. After the reaction is completed, the mixture is evaporated under reduced pressure to remove acetic anhydride and acetic acid. Benzene is added to the residue, and the mixture is evaporated under reduced pressure to remove acetic anhydride and acetic acid. The residue thus obtained is recrystallized from a mixture of ethanol and ether. 0.87 g of (±)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-7-methoxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride 1/2 hydrate is obtained. Yield: 78%

Provenance & Evidence