Acetic Anhydride → HCID 86740807, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.618 g of (±)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-6,7-dimethyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride, 6 ml of acetic anhydride and 6 ml of acetic acid is heated at 105° C. for 18 hours. After the reaction is completed, the mixture is evaporated under reduced pressure to remove solvent. Benzene is added to the residue, and the mixture is evaporated under reduced pressure to remove solvent. The residue is recystallized from a mixture of ethanol and ether. 0.44 g of (±)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-6,7-dimethyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrochloride 3/2 H2O is obtained.

Provenance & Evidence