Ethanol → HCID 70506830, compound

HRID 280548Notes

Reaction equation

HRID 280548 reaction equation
[Br:1][C:2]1([CH:16]=[CH:15][N:14]=[C:13]([C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:12]1)[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[CH2:25]([OH:27])C.[OH-].[K+].[OH-].[Na+].[CH3:32]O>>[CH3:32][O:4][C:3]([O:27][CH3:25])([NH:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:2]1([Br:1])[CH:16]=[CH:15][N:14]=[C:13]([C:17](=[O:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:12]1

Participants

6

Reactant 5

HCID 702EthanolHCID 887MethanolHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 70457227HCID 70457227, compound

Product 1

HCID 70506830HCID 70506830, compoundYield 80%

Procedure

4-Bromo-2-benzoyl-isonicotinanilide (12.7 g) was treated as in Synthesis 11 except that ethyl alcohol was replaced by methyl alcohol and potassium hydroxide by sodium hydroxide (3 g). The titled compound was obtained in an amount of 11.4 g (yield: 80%). m.p. 189°-190° C.

Sources & evidence

ORD record
ord-053da67ed08e48e4b420783b85636527
Source dataset
uspto-grants-1986_05
Patent number
US04590198

Reaction notes

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