HCID 23320874, compound → HCID 19764523, compound

Participants

Reaction Steps

The ester from above (297 mg, 0.77 mmol) was dissolved in 10 mL of methanol with 4 mL of 1M potassium hydroxide and stirred overnight at room temperature. The solvent was removed under vacuum and the residue was redissolved in 20 mL of water and extracted with two 20 mL portions of ether. The aqueous layer was adjusted to a pH of 7 with 1M hydrochloric acid and the powdery precipitate was collected by filtration to give 165 mg of (E)-3-(6-(N-(2-dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid as the dihydrate, mp. 75°-81°. Calc. for C20H25N3O3.2H2O: C, 61.36; H, 7.47; N, 10.73. Found: C, 61.26; H, 7.44; N, 10.67.

Provenance & Evidence