反应详情

A solution of 2-methylbenzofuran-5-carbonitrile (J. Het. Chem., 4, 441, 1967) (1.52 g) and sulphuryl chloride (1.49 g) in chloroform (25 ml) was heated under reflux for 9 hours and then cooled. The solution was washed successively with water, dilute sodium hydroxide solution, water and then dried (Na2SO4). Evaporation of the solvent gave a solid which was crystallised twice from methanol to give 3-chloro-2-methylbenzofuran-5-carbonitrile (0.45 g), m.p. 131.5°-133.5°.

1. temperatureunder reflux for 9 hours
2. temperaturecooled
3. washThe solution was washed successively with water, dilute sodium hydroxide solution, water
4. dry with materialdried (Na2SO4)
5. customEvaporation of the solvent
6. customgave a solid which
7. customwas crystallised twice from methanol