Cyanoacetamide → HCID 13649668, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of sodium (276 mg, 12.0 mmol) in absolute ethanol (28 ml) at 60° C. was added 2-cyanoacetamide (952 mg, 11.3 mmol). The mixture was stirred 5 minutes, 3-chloro-4-(4-chlorophenylthio)benzyl azide (1.8 g, 5.8 mmol) was added, and the mixture was refluxed for 1 hour. The mixture was cooled to 0° C. and filtered. The solid product was washed with ethanol (2X), water (4X), ethanol (2X), and diethyl ether, and air dried to provide 1.67 g (73%) of 5-amino-1-(3-chloro-4-[4-chlorophenylthio]-benzyl)-1,2,3-triazole-4-carboxamide, m.p. 202°-203.5° C.

Provenance & Evidence