HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 3-(Piperazin-1-yl)isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 3-Chloroisoquinoline | HCID 640968 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | 3-(Piperazin-1-yl)isoquinoline | HCID 13025569 | 92.1% |
Reaction Steps
2.0 g of 3-chloroisoquinoline are boiled under reflux for 120 hours with 20 g of piperazine in 100 ml of diethylene glycol dimethyl ether. Working up as in Example 1 gives 2.4 g of 3-(piperazin-1-yl)-isoquinoline, melting point 95°-96°; its hydrochloride decomposes at 266°-268° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04590273 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-bce4116210094e498f296e8bd1c07d3f |
| Source note | uspto-grants-1986_05 |