1-(2-Hydroxyethyl)piperazine → HCID 13025570, compound

HRID 280688Notes

Reaction equation

HRID 280688 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[OH:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[OH:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][N:18]([C:2]2[N:3]=[CH:4][C:5]3[C:10]([CH:11]=2)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:17][CH2:16]1

Participants

4

Reactant 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 6409683-Chloroisoquinoline

Product 1

HCID 13025570HCID 13025570, compound

Procedure

Prepared analogously to Example 1 from 3-chloroisoquinoline and N-(2-hydroxyethyl)-piperazine. Melting point of base 134°-136° C.; melting point of dihydrochloride 282°-283° C.

Workup

  1. customMelting point of base 134°-136° C.

Sources & evidence

ORD record
ord-84dfb34c95e946ff80007951c943b8e9
Source dataset
uspto-grants-1986_05
Patent number
US04590273

Reaction notes

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