HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 5-(3-Allyloxy-4,5-dimethoxybenzyl)-2,4-diaminopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | 3-Demethyltrimethoprim | HCID 12849769 | — |
| Product | 5-(3-Allyloxy-4,5-dimethoxybenzyl)-2,4-diaminopyrimidine | HCID 14570168 | — |
Reaction Steps
The title compound was prepared from 2,4-diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine (20.0 g, 72.4 mmol) and allyl bromide by the procedure of Example 1A. Recrystallization from 95% ethanol gave title compound as white crystals (14.9 g); mp 160°-162°. Anal. Calcd for C16H20N4O3 : C, 60.74; H, 6.37; N, 17.71. Found: C, 60.94; H, 6.45; N, 17.62.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04590271 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-d0121e1c77fc47da9e00f3827c29d37a |
| Source note | uspto-grants-1986_05 |