HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1-propyne → 2,4-Diamino-5-[3,4-dimethoxy-5-(2-propynyloxy)benzyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1-propyne | HCID 12221 | — |
| Reactant | 3-Demethyltrimethoprim | HCID 12849769 | — |
| Product | 2,4-Diamino-5-[3,4-dimethoxy-5-(2-propynyloxy)benzyl]pyrimidine | HCID 12849803 | — |
Reaction Steps
The title compound was prepared from 2,4-diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine and propargyl chloride by the procedure of Example 1A. Recrystallization from 95% ethanol gave off-white needles (73%); mp 160°-161°. Anal. Calcd for C16H18N4O3 : C, 61.13; H, 5.77; N, 17.82. Found: C, 60.96; H, 5.80; N, 17.75.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04590271 |
| Source dataset | uspto-grants-1986_05 |
| ORD ID | ord-cd5b4193e470421c87949e6860dd0a08 |
| Source note | uspto-grants-1986_05 |