Acetone → HCID 13671457, compound

Participants

Reaction Steps

A mixture of 3-[4-(1-methylpropoxy)phenoxy]-1,2-propanediol (1.0 g, 4.2 mmol), acetone (0.24 g, 4.2 mmol) and p-toluenesulfonic acid (0.03 g) in 20 ml of petroleum ether is heated under reflux for 7 hours. Water generated from the reaction is removed. The final solution is concentrated to remove the solvent and the product is purified by column chromatography to give 2,2-dimethyl-4-[4-(1-methylpropoxy)phenoxymethyl]-1,3-dioxolane, MS m/e 280 (M+).

Provenance & Evidence